Obesity is a complex, chronic disease that requires ongoing care and support. As a physician with board certifications in obesity medicine, lifestyle medicine and internal medicine, I have a unique and thorough understanding of obesity and weight loss medicine and am able to provide comprehensive and effective treatments for it. Medications can be an effective tool in weight loss medicine when used in combination with lifestyle changes such as healthy eating and regular physical activity.
There are several medications that are commonly prescribed to treat obesity and achieve weight loss.
These medications work by either suppressing appetite, increasing the feeling of fullness, or by blocking the absorption of fat.
Phentermine (Lomaira, Adipex-P):
One of the most commonly prescribed medications for obesity is Phentermine, marketed under the brand names Lomaira and Adipex-P. Phentermine (Lomaira, Adipex-P) is a stimulant that suppresses appetite by increasing levels of certain chemicals in the brain. It is usually prescribed for short-term use, typically for a few weeks to a few months, and is often used in combination with other medications and lifestyle changes.
Lorcaserin (Belviq):
Another medication commonly prescribed for obesity is Lorcaserin, marketed under the brand name Belviq. Lorcaserin (Belviq) works by activating a specific type of serotonin receptor in the brain that helps to control appetite. It is taken once a day, and has been shown to help people lose weight and keep it off over the long-term.
Orlistat (Xenical and Alli):
Orlistat, marketed under the common brands Xenical and Alli, is another medication that is commonly prescribed for obesity. Orlistat (Xenical, Alli) works by preventing the absorption of fat by the body. Orlistat is taken with meals, and has been shown to help people lose weight and keep it off over the long-term.
Bupropion and naltrexone:
Bupropion and naltrexone are also medications that are commonly prescribed for obesity. They work by modulating the levels of certain chemicals in the brain that are involved in appetite and satiety. They are usually taken in combination with other medications, such as phentermine or lorcaserin, and are often used in combination with lifestyle changes.
Ozempic (semaglutide):
Ozempic is a GLP-1 receptor agonist medication, administered as a once-weekly injectable. Initially developed for type 2 diabetes management, it has also been approved as a weight loss medication. Ozempic works by mimicking the actions of the GLP-1 hormone, which regulates blood sugar levels and appetite. Clinical trials have shown significant weight loss in patients using Ozempic, making it a valuable option for those struggling with obesity. As an obesity medicine physician, I consider Ozempic for patients who have not achieved adequate weight loss through lifestyle changes alone and need additional support to reach their weight loss goals.
Wegovy (semaglutide):
Wegovy is a higher-dose formulation of semaglutide, specifically developed and approved as a weight loss medication. Like Ozempic, it is a once-weekly injectable GLP-1 receptor agonist. Wegovy has demonstrated even greater effectiveness in promoting weight loss compared to Ozempic, making it a compelling option for patients with severe obesity or those who have not responded well to other weight loss interventions. As a physician, I reserve Wegovy for patients who require more aggressive weight management due to their high BMI or other risk factors.
Mounjaro (tirzepatide) – noteworthy new medication:
Tirzepatide is an exciting new GLP-1 and glucagon receptor dual agonist medication. It has FDA approval for type 2 diabetes and is currently pending approval for weight loss and we expect that approval shortly. Early trial results have shown promising weight loss outcomes, potentially surpassing the efficacy of Ozempic and Wegovy. As an obesity medicine physician, I keep a close eye on the progress of tirzepatide’s development and eagerly await its potential approval as an additional option for my patients.
Rybelsus (semaglutide in tablet form):
Rybelsus is also a GLP-1 receptor agonist, but unlike Ozempic and Wegovy, it is available in an oral tablet form. This makes it a convenient option for patients who prefer not to use injectable medications. Initially developed for treating type 2 diabetes, Rybelsus has also been approved as a weight loss medication. It helps regulate blood sugar levels, suppresses appetite, and contributes to weight loss. As an obesity medicine physician, I consider Rybelsus for patients who are not comfortable with injections or who may prefer the convenience of an oral tablet.
It’s important to note that these medications come with certain risks and side effects, and it’s important to have a discussion with a medical professional about the potential benefits and risks of these medications. It’s also important to know that these medications are not a magic solution for weight loss, they should be use as part of a comprehensive treatment plan that includes lifestyle changes.
In conclusion, there are a variety of medications available to help people with obesity lose weight and improve their overall health. However, it’s important to work with a qualified healthcare professional to determine the best course of treatment and to monitor progress. It is my opinion that these medications are best prescribed and managed by a board certified obesity medicine physician such as myself. Remember that weight loss is a long-term process that requires ongoing care and support.
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Live well,
Dr. Aubre A. Weber | CEO & Founder of Synergy
Diplomate – American Board of Internal Medicine
Diplomate – American Board of Lifestyle Medicine
Diplomate – American Board of Obesity Medicine